Overview and Approach to Breast Pathology
Breast Anatomy and Physiology The breast is an organ whose structure reflects its unique function: lactation milk production (breastfeeding). The epithelial component of the tissue consists of milk-producing lobules that connect to ducts that lead to the nipple. The majority of breast cancers arise from the cells that form the lobules and terminal ducts. These lobules and ducts are distributed throughout the breast's background fibrous tissue and adipose tissue (fat). The male breast structure is nearly identical to that of the female breast, with the exception that male breast tissue lacks the specialized lobules because males have no physiological need for milk production . Breast cancer is the most common non-skin cancer in women and the second leading cause of cancer death. Despite an increase in breast cancer incidence, advances in diagnosis and treatment have resulted in a decrease in mortality. A growing range of local and systemic therapy options has resulted in mo