Adult Breast Cancer Treatment-Patient Version

Adult Breast Cancer Treatment-Patient Version

Certain factors affect prognosis (chance of recovery) and treatment options.

Breast cancer is a disease in which malignant (cancer) cells form in the tissues of the breast.

The breast is made up of lobes and ducts. Each breast has 15 to 20 sections called lobes. Each lobe has many smaller sections called lobules. Lobules end in dozens of tiny bulbs that can make milk. The lobes, lobules, and bulbs are linked by thin tubes called ducts.

Each breast also has blood vessels and lymph vessels. The lymph vessels carry an almost Colorless, watery fluid called lymph. Lymph vessels carry lymph between lymph nodes. Lymph nodes are small, bean-shaped structures found throughout the body. They filter lymph and store white blood cells that help fight infection and disease. Groups of lymph nodes are found near the breast in the axilla (under the arm), above the collarbone, and in the chest.

The most common type of breast cancer is ductal carcinoma, which begins in the cells of the ducts. Cancer that begins in the lobes or lobules is called lobular carcinoma and is more often found in both breasts than are other types of breast cancer. Inflammatory breast cancer is an uncommon type of breast cancer in which the breast is warm, red, and swollen.

A family history of breast cancer and other factors increases the risk of breast cancer.

Anything that increases your chance of getting a disease is called a risk factor. Having a risk factor does not mean that you will get cancer; not having risk factors doesn't mean that you will not get cancer. Talk to your doctor if you think you may be at risk for breast cancer.

Risk factors for breast cancer include the following:

A personal history of invasive breast cancer, ductal carcinoma in situ (DCIS), or lobular carcinoma in situ (LCIS).

A personal history of benign (noncancer) breast disease.

A family history of breast cancer in a first-degree relative (mother, daughter, or sister).

Inherited changes in the BRCA1 or BRCA2 genes or in other genes increase the risk of breast cancer.

Breast tissue that is dense on a mammogram.

Exposure of breast tissue to estrogen made by the body. This may be caused by:

Menstruating at an early age.

Older age at first birth or never having given birth.

Starting menopause at a later age.

Taking hormones such as estrogen combined with progestin for symptoms of menopause.

Treatment with radiation therapy to the breast/chest.

Drinking alcohol.

Older age is the main risk factor for most cancers. The chance of getting cancer increases as you get older.

NCI's Breast Cancer Risk Assessment Tool uses a woman's risk factors to estimate her risk for breast cancer during the next five years and up to age 90. This online tool is meant to be used by a healthcare provider. For more information on breast cancer risk, call 1-800-4-CANCER.

Breast cancer is sometimes caused by inherited gene mutations (changes).

The genes in cells carry the hereditary information that is received from a person’s parents. Hereditary breast cancer makes up about 5% to 10% of all breast cancer. Some mutated genes related to breast cancer are more common in certain ethnic groups.

Women who have certain gene mutations, such as a BRCA1 or BRCA2 mutation, have an increased risk of breast cancer. These women also have an increased risk of ovarian cancer and may have an increased risk of other cancers. Men who have mutated genes related to breast cancer also have an increased risk of breast cancer. For more information, see Male Breast Cancer Treatment.

There are tests that can detect (find) mutated genes. These genetic tests are sometimes done for members of families with a high risk of cancer. For more information, see Genetics of Breast and Gynecologic Cancers.

The use of certain medicines and other factors decreases the risk of breast cancer.

Anything that decreases your chance of getting a disease is called a protective factor.

Protective factors for breast cancer include the following:

Take any of the following:

Estrogen-only hormone therapy after a hysterectomy.

Selective estrogen receptor modulators (SERMs).

Aromatase inhibitors.

Less exposure of breast tissue to estrogen made by the body. This can be a result of:

Early pregnancy.

Breastfeeding.

Getting enough exercise.

Having any of the following procedures:

Mastectomy to reduce the risk of cancer.

Oophorectomy to reduce the risk of cancer.

Ovarian ablation.

Signs of breast cancer include a lump or change in the breast.

These and other signs may be caused by breast cancer or by other conditions. Check with your doctor if you have any of the following:

A lump or thickening in or near the breast or in the underarm area.

A change in the size or shape of the breast.

A dimple or puckering in the skin of the breast.

A nipple turned inward into the breast.

Fluid, other than breast milk, from the nipple, especially if it's bloody.

Scaly, red, or swollen skin on the breast, nipple, or areola (the dark area of skin around the nipple).

Dimples in the breast that look like the skin of an orange, are called peau d’orange.

Tests that examine the breasts are used to diagnose breast cancer.

Check with your doctor if you notice any changes in your breasts. The following tests and procedures may be used:

Physical exam and health history: An exam of the body to check general signs of health, including checking for signs of disease, such as lumps or anything else that seems unusual. A history of the patient’s health habits and past illnesses and treatments will also be taken.

Clinical breast exam (CBE): An exam of the breast by a doctor or other health professional. The doctor will carefully feel the breasts and under the arms for lumps or anything else that seems unusual.

Ultrasound exam: A procedure in which high-energy sound waves (ultrasound) are bounced off internal tissues or organs and make echoes. The echoes form a picture of body tissues called a sonogram. The picture can be printed to be looked at later.

MRI (magnetic resonance imaging): A procedure that uses a magnet, radio waves, and a computer to make a series of detailed pictures of both breasts. This procedure is also called nuclear magnetic resonance imaging (NMRI).

Blood chemistry studies: A procedure in which a blood sample is checked to measure the amounts of certain substances released into the blood by organs and tissues in the body. An unusual (higher or lower than normal) amount of a substance can be a sign of disease.

Biopsy: The removal of cells or tissues so they can be viewed under a microscope by a pathologist to check for signs of cancer. If a lump in the breast is found, a biopsy may be done.

Estrogen and progesterone receptor test: A test to measure the amount of estrogen and progesterone (hormones) receptors in cancer tissue. If there are more estrogen and progesterone receptors than normal, the cancer is called estrogen and/or progesterone receptor positive. This type of breast cancer may grow more quickly. The test results show whether treatment to block estrogen and progesterone may stop cancer from growing.

Multigene tests: Tests in which samples of tissue are studied to look at the activity of many genes at the same time. These tests may help predict whether cancer will spread to other parts of the body or recur (come back).

There are many types of multigene tests. The following multigene tests have been studied in clinical trials:

Oncotype DX: This test helps predict whether early-stage breast cancer that is estrogen receptor positive and node negative will spread to other parts of the body. If the risk that cancer will spread is high, chemotherapy may be given to lower the risk.

MammaPrint: A laboratory test in which the activity of 70 different genes is looked at in the breast cancer tissue of women who have early-stage invasive breast cancer that has not spread to lymph nodes or has spread to 3 or fewer lymph nodes. The activity level of these genes helps predict whether breast cancer will spread to other parts of the body or come back. If the test shows that the risk that cancer will spread or come back is high, chemotherapy may be given to lower the risk.

Based on these tests, breast cancer is described as one of the following types:

Hormone receptor-positive (estrogen and/or progesterone receptor positive) or hormone receptor-negative (estrogen and/or progesterone receptor negative).

HER2/neu positive or HER2/neu negative.

Triple-negative (estrogen receptor, progesterone receptor, and HER2/neu negative).

This information helps the doctor decide which treatments will work best for your cancer.

Certain factors affect prognosis (chance of recovery) and treatment options.

The prognosis and treatment options depend on the following:

The stage of cancer (the size of the tumor and whether it is in the breast only or has spread to lymph nodes or other places in the body).

The type of breast cancer.

Estrogen receptor and progesterone receptor levels in the tumor tissue.

Human epidermal growth factor type 2 receptor (HER2/neu) levels in the tumor tissue.

Whether the tumor tissue is triple negative (cells that do not have estrogen receptors, progesterone receptors, or high levels of HER2/neu).

How fast the tumor is growing.

How likely the tumor is to recur (come back).

A woman’s age, general health, and menopausal status (whether a woman is still having menstrual periods).

Whether cancer has just been diagnosed or has recurred (come back).

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https://www.blogger.com/blog/post/edit/3238443600245550728/7246086302346767315 10th World Breast Pathology and Breast Cancer Conference | LinkedIn

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